Tuesday, January 29, 2013

Immigration overhaul? GOP, Dem senators vow action

Sen. Marco Rubio, R-Fla., center, takes a reporter's question as a bipartisan group of leading senators announce that they have reached agreement on the principles of sweeping legislation to rewrite the nation's immigration laws, during a news conference at the Capitol in Washington, Monday, Jan. 28, 2013. From left are Sen. John McCain, R-Ariz., Sen. Charles Schumer, D-N.Y., and Sen. Marco Rubio, R-Fla. The deal covers border security, guest workers and employer verification, as well as a path to citizenship for the 11 million illegal immigrants already in this country. (AP Photo/J. Scott Applewhite)

Sen. Marco Rubio, R-Fla., center, takes a reporter's question as a bipartisan group of leading senators announce that they have reached agreement on the principles of sweeping legislation to rewrite the nation's immigration laws, during a news conference at the Capitol in Washington, Monday, Jan. 28, 2013. From left are Sen. John McCain, R-Ariz., Sen. Charles Schumer, D-N.Y., and Sen. Marco Rubio, R-Fla. The deal covers border security, guest workers and employer verification, as well as a path to citizenship for the 11 million illegal immigrants already in this country. (AP Photo/J. Scott Applewhite)

Sen. John McCain, R-Ariz., left, and Sen. Charles Schumer, D-N.Y., right, confer as they and other leading senators announce that they have reached agreement on the principles of sweeping legislation to rewrite the nation's immigration laws, during a news conference at the Capitol in Washington, Monday, Jan. 28, 2013. The deal covers border security, guest workers and employer verification, as well as a path to citizenship for the 11 million illegal immigrants already in this country. (AP Photo/J. Scott Applewhite)

Rep. Joe Garcia, D-Fla, states his support for immigrants and pledges to work in favor of immigration reform to reporters as immigration reform activists protest in front of Freedom Tower in downtown Miami, Monday, Jan. 28, 2013. The Florida Immigrant Coalition, together with other immigrant families and community organizations, have initiated the "Di Que Si!" campaign, which translates into English "Say yes!," demanding immigration reform that creates a system that keeps families united. Activists and immigrants also asked for the suspension of deportations as lawmakers work on immigration reform, and announced they will join a national mobilization in favor of immigration reform in Washington D.C. on April 10. (AP Photo/Alan Diaz)

Press Secretary Jay Carney briefs reporters at the White House in Washington, Monday, Jan. 28, 2013. (AP Photo/Charles Dharapak)

A bipartisan group of leading senators announce that they have reached agreement on the principles of sweeping legislation to rewrite the nation's immigration laws, during a news conference at the Capitol in Washington, Monday, Jan. 28, 2013. From left are Sen. John McCain, R-Ariz., Sen. Charles Schumer, D-N.Y., Sen. Marco Rubio, R-Fla., and Sen. Robert Menendez, D-N.J. The deal covers border security, guest workers and employer verification, as well as a path to citizenship for the 11 million illegal immigrants already in this country. (AP Photo/J. Scott Applewhite)

WASHINGTON (AP) ? Side by side, leading Democratic and Republican senators pledged Monday to propel far-reaching immigration legislation through the Senate by summer providing a possible path to citizenship for an estimated 11 million people now in the U.S. illegally.

The senators acknowledged pitfalls that have doomed such efforts in the past, but they suggested that November's elections ? with Hispanics voting heavily for President Barack Obama and other Democrats ? could make this time different.

Passage of the emotionally charged legislation by the Democratic-controlled Senate is far from assured, and a taller hurdle could come later in the House, which is dominated by conservative Republicans who've shown little interest in immigration overhaul. Obama will lay out his own proposals Tuesday, most of which mirror the Senate plans.

Besides the citizenship provision, including new qualifications, the Senate measure would increase border security, allow more temporary workers to stay and crack down on employers who would hire illegal immigrants. The plans are still short on detail, and all the senators conceded that months of tedious and politically treacherous negotiations lie ahead.

But with a re-elected Obama pledging his commitment, the lawmakers argued that six years after the last sustained congressional effort at an immigration overhaul came up short in the Senate, chances for approval this year are much better.

"Other bipartisan groups of senators have stood in the same spot before, trumpeting similar proposals," said Sen. Charles Schumer, D-N.Y. "But we believe this will be the year Congress finally gets it done. The politics on this issue have been turned upside down," Schumer said, arguing that polls show more support than ever for immigration changes and political risk in opposing it.

"Elections. Elections," said Sen. John McCain, R-Ariz. "The Republican Party is losing the support of our Hispanic citizens. And we realize that there are many issues on which we think we are in agreement with our Hispanic citizens, but this is a pre-eminent issue with those citizens."

Obama got 71 percent of the Latino vote in November compared to 27 percent for Republican Mitt Romney.

The president will endorse the Senate process during an event in Las Vegas Tuesday, administration officials said. He will outline a similar vision for overhauling the nation's immigration laws, drawing on the immigration "blueprint" he first released in 2011.

The blueprint focuses on four key areas: a pathway to citizenship for the 11 million illegal immigrants in the U.S., improved border security, an overhaul of the legal immigration system and making it easier for businesses to verify the legal status of workers.

Seeking to ramp up pressure on lawmakers, the White House has prepared formal immigration legislation that it could sent to Capitol Hill should the Senate process stall, administration officials said. The officials spoke on the condition of anonymity in order to discuss internal strategy.

Like the president's blueprint, the Senate proposals also call for a path to citizenship for illegal immigrants already here. But lawmakers want the creation of that pathway to be contingent upon securing the border and better tracking of people in the U.S. on visas.

The Senate's five-page framework also calls for overhauling the legal immigration system, including awarding green cards to immigrants who obtain certain advanced degrees from American universities, creating an effective high-tech employment verification system to ensure that employers do not hire illegal immigrants in the future and allowing more low-skill and agricultural workers.

In a sign of the challenges ahead, the proposals immediately got a cool reaction from Senate Republican Leader Mitch McConnell of Kentucky.

"This effort is too important to be written in a back room and sent to the floor with a take-it-or-leave it approach," McConnell said. "It needs to be done on a bipartisan basis and include ideas from both sides of the aisle."

Sen. Jeff Sessions, R-Ala., said on the Senate floor, "No one should expect members of the Senate are just going to rubber-stamp what a group has met and decided."

Sen. Ted Cruz, R-Texas, said he was concerned about the proposed path to citizenship.

"To allow those who came here illegally to be placed on such a path is both inconsistent with rule of law and profoundly unfair to the millions of legal immigrants who waited years, if not decades, to come to America legally," said Cruz.

A year after Border Patrol apprehensions of illegal border crossers plunged to the lowest levels in nearly 40 years agents have seen a slight increase in arrests, according to Border Patrol arrest data obtained by The Associated Press. In the budget year that ended in September, Border Patrol agents arrested 356,873 would-be border crossers along the Mexican border. In fiscal year 2011, agents along the Mexican border made 327,577 arrests.

Senate Majority Leader Harry Reid, D-Nev., applauded the framework and said, "I will do everything in my power to get a bill across the finish line."

Pressures from outside groups from business to organized labor to immigrants themselves will be immense, even as lawmakers warily eye voters for their reaction.

Besides McCain and Schumer, the senators endorsing the new principles Monday were Democrats Dick Durbin of Illinois, Robert Menendez of New Jersey and Michael Bennet of Colorado and Republicans Lindsey Graham of South Carolina, Marco Rubio of Florida and Jeff Flake of Arizona.

Several of them have worked for years on the issue. McCain collaborated with the late Democratic Sen. Edward M. Kennedy on the comprehensive immigration legislation pushed by then-President George W. Bush that failed in 2007.

The group claims a notable newcomer in Rubio, a potential 2016 presidential candidate whose conservative bona fides may help smooth the way for support among conservatives wary of anything that smacks of amnesty. Rubio has been working with the group while also detailing his own similar immigration proposals to selected media, getting a generally positive reaction from conservative media.

"There are 11 million human beings in this country today that are undocumented. That's not something that anyone is happy about; that's not something that anyone wanted to see happen, but that is what happened. And we have an obligation and the need to address the reality of the situation that we face," Rubio said Monday.

As the group turns to the work of writing legislation, which they hope to see come to a vote in the Senate Judiciary Committee in March, there may be most disagreement over the path to staying in the U.S. legally. In order to satisfy the concerns of Rubio and other Republicans, the senators are calling for the completion of steps on border security and oversight of those here on visas before taking major steps forward on the path to citizenship.

Even then, those here illegally would have to pass background checks and pay fines and taxes in order to qualify for a "probationary legal status" that would allow them to live and work here ? and not qualify for federal benefits ? before being able to apply for permanent residency, a critical step toward citizenship. Once they are allowed to apply they would do so behind everyone else already in line for a green card within the current immigration system.

That could be a highly cumbersome process, but how to make it more workable is being left to future negotiations. The senators envision a more streamlined process toward citizenship for immigrants brought here as children, and for agricultural workers.

Outside groups including Latino advocacy organizations, the U.S. Chamber of Commerce and organized labor were quick to praise the emerging framework. But some also sounded notes of caution.

Richard Trumka, president of the AFL-CIO, questioned a proposal by the Senate group to require illegal immigrants to provide proof of employment before they can gain legal status. Trumka said it could exclude millions of workers "who cannot prove employment because they have been forced to work off the clock or have no employer by virtue of being independent contractors."

Deepak Bhargava, executive director of the Center for Community Change, questioned the process being set out for the path to citizenship. "If the details are not done correctly, the path to citizenship can take far longer than it is reasonable. There is real concern about those details," he said.

___

Associated Press writers Julie Pace and Luis Alonso Lugo contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-01-28-US-Immigration/id-9a4b34e3600e477c879a9c8fcc205cbe

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Israelis offer a 'Yom Huledet Sameach' to Ben Yehuda, resurrector of Hebrew language

Eliezer Ben Yehuda, who transformed Hebrew from the rusty language of ancient Israel and the Bible into the dynamic, dominant language of modern-day Israel, would be 155 years old today.

By Christa Case Bryant,?Staff Writer / January 8, 2013

This December, 2012 photo shows visitors at the Mahane Yehuda market, one of Jerusalem's free tourist attractions. Beyond its earthly past, Jerusalem has an impossible beauty with broad appeal. For residents and tourists, secular and religious souls, city slickers or nature lovers, there is always an unexplored alleyway, street corner or vista that will show you the city as you?ve never seen it before.

Ariel Schalit/AP

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If it weren?t for Eliezer Ben Yehuda, I wouldn?t be able to order ice cream, ask directions to the local furniture store, or discuss Gaza bombings in Hebrew.

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Since I?m a new journalist in Israel who happens to love ice cream and arrived here with only one piece of furniture to my name, that would be grave indeed.

So I for one am grateful for Mr. Ben Yehuda, who was born 155 years ago today in the Russian empire.

Legend has it that the man was not only brilliant, but a little crazy. And you would have to be, if you were planning to try to resurrect an ancient language after roughly 2,000 years and expect it to become the primary spoken language of a country that didn't even exist yet.

But the Sorbonne-educated Ben Yehuda did just that ??well before the state of Israel was founded in 1948, and even before Lord Balfour of Britain made his famous promise to the Zionists in 1917 to help establish a Jewish homeland.

Of course, Hebrew was the language of the Torah ? the biblical books of Genesis, Exodus, Leviticus, Numbers, and Deuteronomy ? as well as other religious writings. So many Jews were familiar with it. But they didn?t use it to talk about things like grocery shopping or even politics.

Where to start? With your family, of course. When Ben Yehuda arrived in Israel with his family, he banned his wife and children from speaking any other language. According to tradition, his family was the first to speak exclusively Hebrew in the home.

He also helped start schools and Hebrew-language newspapers, and published the first dictionary of modern Hebrew, often drawing on biblical words to coin modern terms. Ultra-Orthodox Jews pushed back hard, arguing that Hebrew is a holy language and not to be used to discuss the mundane. Many of them still prefer to speak in Yiddish when discussing daily affairs.

But Hebrew is nevertheless the dominant language in Israel today, although Arabic is an official language as well.

But I digress.

You were wondering about how to order ice cream, right?

G'lida. That?s your ticket.

Todah (thank you), Ben Yehuda.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/8b6aRSWoayI/Israelis-offer-a-Yom-Huledet-Sameach-to-Ben-Yehuda-resurrector-of-Hebrew-language

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Report links A-Rod with PED use; MLB investigates

FILE - In this Wednesday, Oct. 17, 2012 file photo, New York Yankees' Alex Rodriguez takes batting practice before Game 4 of the American League championship series against the Detroit Tigers, in Detroit. Major League Baseball says it is "extremely disappointed" about a new report that says records from an anti-aging clinic in the Miami area link Rodriguez and other players to the purchase of performance-enhancing drugs. (AP Photo/Carlos Osorio, File)

FILE - In this Wednesday, Oct. 17, 2012 file photo, New York Yankees' Alex Rodriguez takes batting practice before Game 4 of the American League championship series against the Detroit Tigers, in Detroit. Major League Baseball says it is "extremely disappointed" about a new report that says records from an anti-aging clinic in the Miami area link Rodriguez and other players to the purchase of performance-enhancing drugs. (AP Photo/Carlos Osorio, File)

FILE - In this Oct. 18, 2012 file photo, New York Yankees' Alex Rodriguez prepares to hit in the sixth inning during Game 4 of the American League championship series against the Detroit Tigers in Detroit. Major League Baseball says it is "extremely disappointed" about a new report that says records from an anti-aging clinic in the Miami area link Rodriguez and other players to the purchase of performance-enhancing drugs. (AP Photo/Matt Slocum, File)

(AP) ? Major League Baseball said it is "extremely disappointed" about new allegations of performance-enhancing drug use against Alex Rodriguez and other players contained in a newspaper report.

The Miami New Times, a popular alternative weekly, said in a story Tuesday that it had obtained files through an employee at a recently closed clinic in south Florida that show Rodriguez purchased HGH and other substances.

"We are always extremely disappointed to learn of potential links between players and the use of performance-enhancing substances. ... Through our Department of Investigations, we have been actively involved in the issues in South Florida," MLB's statement said.

Rodriguez, the New York Yankees slugger currently recovering from hip surgery, has admitted using steroids from 2001-03 but insisted he stopped after that.

"We fully support the Commissioner's Joint Drug Prevention and Treatment Program. This matter is now in the hands of the Commissioner's Office," the Yankees said in a statement. "We will have no further comment until that investigation has concluded."

Other players named by the New Times as appearing in the records at Biogenesis include Melky Cabrera, Gio Gonzalez, Bartolo Colon and Nelson Cruz. Cabrera, the All-Star game MVP for the San Francisco Giants last season, was suspended 50 games in August for failing a drug test. The outfielder has signed with the Toronto Blue Jays as a free agent.

Colon, a pitcher for the Oakland A's, was also suspended 50 games in August.

Gonzalez, who went 21-8 for the Washington Nationals last season, and Cruz, who hit 24 home runs for the Texas Rangers, had not previously been linked to performance-enhancing drugs.

The Rangers said in a statement that after being contacted by the New Times late last week, they notified Major League Baseball. The club said it had no further comment.

Gonzalez posted on his Twitter feed: "I've never used performance enhancing drugs of any kind and I never will, I've never met or spoken with tony Bosch or used any substance."

The report said that the notes of clinic chief Anthony Bosch list the players' names and the substances they received, including human growth hormone and steroids. Several unidentified employees and clients confirmed to the publication that the clinic distributed the substances, the paper said. The employees said that Bosch bragged of supplying drugs to professional athletes but they never saw the sports stars in the office.

Any player found by MLB to use banned, performance-enhancing substances, is subject to suspension.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-01-29-MLB-Drug%20Investigation/id-f7ddaae44e3f4d43ab6713aa69d296bc

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Fitness Buzz: How To Pick a Personal Trainer Who is Right For You ...

Trips to the gym are all well and good, but fitness buffs know that the best results come with a personal trainer. Having somebody pay close attention to your diet and exercise routine will help you tailor your activities to get the body you want. If you?re looking for a trainer, here are a few useful things to keep in mind. Be sure to consult with your doctor before beginning any new fitness or exercise regimen!

The best personal trainers are educated and certified through a personal training organization. It?s not necessary to have a college degree to take you through a workout, but the more knowledge they have about nutrition and body function, the better they can tailor your regimen to your needs.

Look for a trainer that has experience working with people with similar fitness needs. If you?re just looking to lose some weight, you probably don?t want to go with the guy who trains competitive bodybuilders. Make sure your needs and their skills match.

Make sure that your trainer has a methodology for tracking your progress. You want to be able to quantify the improvements that you?re getting in your health, and most good trainers will have statistics that they will monitor to ensure you?re getting your money worth.

If you have any medical conditions, make sure your trainer knows about them before you first session. No matter how shy you are about them, it?s vital that they know.

Source: http://www.respage.com/blog/portocall/port-o-call-hotel/2013/01/fitness-buzz-how-to-pick-a-personal-trainer-who-is-right-for-you/

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Patients' own skin cells are transformed into heart cells to create 'disease in a dish'

Jan. 27, 2013 ? Most patients with an inherited heart condition known as arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) don't know they have a problem until they're in their early 20s. The lack of symptoms at younger ages makes it very difficult for researchers to study how ARVD/C evolves or to develop treatments. A new stem cell-based technology created by 2012 Nobel Prize winner Shinya Yamanaka, M.D., Ph.D., helps solve this problem. With this technology, researchers can generate heart muscle cells from a patient's own skin cells. However, these newly made heart cells are mostly immature. That raises questions about whether or not they can be used to mimic a disease that occurs in adulthood.

In a paper published January 27 in Nature, researchers at Sanford-Burnham Medical Research Institute and Johns Hopkins University unveil the first maturation-based "disease in a dish" model for ARVD/C. The model was created using Yamanaka's technology and a new method to mimic maturity by making the cells' metabolism more like that in adult hearts. For that reason, this model is likely more relevant to human ARVD/C than other models and therefore better suited for studying the disease and testing new treatments.

"It's tough to demonstrate that a disease-in-a-dish model is clinically relevant for an adult-onset disease. But we made a key finding here -- we can recapitulate the defects in this disease only when we induce adult-like metabolism. This is an important breakthrough considering that ARVD/C symptoms usually don't arise until young adulthood. Yet the stem cells we're working with are embryonic in nature," said Huei-Sheng Vincent Chen, M.D., Ph.D., associate professor at Sanford-Burnham and senior author of the study.

To establish this model, Chen teamed up with expert ARVD/C cardiologists Daniel Judge, M.D., Joseph Marine, M.D., and Hugh Calkins, M.D., at Johns Hopkins University. Johns Hopkins is home to one of the largest ARVD/C patient registries in the world.

"There is currently no treatment to prevent progression of ARVD/C, a rare disorder that preferentially affects athletes. With this new model, we hope we are now on a path to develop better therapies for this life-threatening disease," said Judge, associate professor and medical director of the Center for Inherited Heart Disease at the Johns Hopkins University School of Medicine.

Disease in a dish

To recreate a person's own unique ARVD/C in the lab, the team first obtained skin samples from ARVD/C patients with certain mutations believed to be involved in the disease. Next they performed Yamanaka's technique: adding a few molecules that dial back the developmental clock on these adult skin cells, producing embryonic-like induced pluripotent stem cells (iPSCs). The researchers then coaxed the iPSCs into producing an unlimited supply of patient-specific heart muscle cells. These heart cells were largely embryonic in nature, but carried along the original patient's genetic mutations.

However, for nearly a year, no matter what they tried, the team couldn't get their ARVD/C heart muscle cells to show any signs of the disease. Without actual signs of adult-onset ARVD/C, these young, patient-specific heart muscle cells were no use for studying the disease or testing new therapeutic drugs.

Speeding up time

Eventually, the team experienced the big "aha!" moment they'd been looking for. They discovered that metabolic maturity is the key to inducing signs of ARVD/C, an adult disease, in their embryonic-like cells. Human fetal heart muscle cells use glucose (sugar) as their primary source of energy. In contrast, adult heart muscle cells prefer using fat for energy production. So Chen's team applied several cocktails to trigger this shift to adult metabolism in their model.

After more trial and error, they discovered that metabolic malfunction is at the core of ARVD/C disease. Moreover, Chen's team tracked down the final piece of puzzle to make patient-specific heart muscle cells behave like sick ARVD/C hearts: the abnormal over-activation of a protein called PPAR?. Scientists previously attributed ARVD/C to a problem in weakened connections between heart muscle cells, which occur only in half of the ARVD/C patients. With the newly established model, they not only replicated this adult-onset disease in a dish, but also presented new potential drug targets for treating ARVD/C.

What's next?

Chen's team was recently awarded a new grant from the California Institute for Regenerative Medicine to create additional iPSC-based ARVD/C models. With more ARVD/C models, they will determine whether or not all (or at least most) patients develop the disease via the same metabolic defects discovered in this current study.

Together with the Johns Hopkins team, Chen also hopes to conduct preclinical studies to find a new therapy for this deadly heart condition.

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Story Source:

The above story is reprinted from materials provided by Sanford-Burnham Medical Research Institute, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Changsung Kim, Johnson Wong, Jianyan Wen, Shirong Wang, Cheng Wang, Sean Spiering, Natalia G. Kan, Sonia Forcales, Pier Lorenzo Puri, Teresa C. Leone, Joseph E. Marine, Hugh Calkins, Daniel P. Kelly, Daniel P. Judge, Huei-Sheng Vincent Chen. Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs. Nature, 2013; DOI: 10.1038/nature11799

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/SopuqUp_z60/130127134201.htm

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