Thursday, October 25, 2012

Zynga lays off 5% of its work force, ends 13 games

By Gerry Shih, Reuters

SAN FRANCISCO - Zynga Inc laid off 5 percent of its full-time workforce and shut its Boston office on Tuesday as it embarked on a sweeping cost-cutting campaign that may eventually see the "FarmVille" game creator close its Japanese and British studios as well.

The company, which is trying to arrest a steep decline in earnings as users gradually migrate onto mobile devices or rival games, plans to "sunset" 13 unspecified older titles, Chief Executive Mark Pincus said in a staff memo on Tuesday that was published on the company blog.

"This is the most painful part of an overall cost reduction plan that also includes significant cuts in spending on data hosting, advertising and outside services, primarily contractors," Pincus wrote in his memo.

Pincus said the cuts would accompany a regime of "more stringent budget and resource allocation around new games and partner projects," hinting at a fundamental change for a company that was known for expanding aggressively through hires and acquisition deals before it went public to fanfare last December.

In March, Pincus made a gamble to acquire game studio OMGPOP for $180 million before acknowledging this month that the deal didn't pan out, leading to a $90 million writedown.

The memo came on the eve of Zynga's earnings report on Wednesday, when Pincus and Chief Financial Officer David Wehner are expected to provide Wall Street with more comprehensive details about the company's overhaul strategy.

Tuesday's cuts were presaged on October 4, when Zynga slashed its 2012 outlook and warned investors that it would record a steep drop in sequential quarterly revenues for the first time since its December initial public offering. At the time, Pincus said the company would examine how to proceed with cuts.

As the first step of Zynga's reduction plan unfolded Tuesday, Pincus said that Zynga would significantly pull back its investment in "The Ville" game - a major recent initiative - and scale back on its Austin, Texas studio as it sought to cut costs. He also said the company was "proposing" to close its Japanese and British offices.

Rumors of the layoffs in Austin and Boston had spread on gaming blogs and over social networks during the day, and the company's shares closed down more than 5 percent, at $2.20. But they bounced back 4.5 percent to $2.30 in after-hours trade, following news of the cost-cutting initiatives.

"It's good to see them be realistic, but the real question is not a matter of profitability, it's 'can you get revenue going the right direction?'" said Ben Schachter, a senior analyst at Macquarie Securities. "The Street doesn't want to see cost-cutting for what was supposed to be a growth company."

Pincus, who grew the company behind such ageing Facebook hits as "CityVille" "and Mafia Wars", will face employees at a quarterly gathering next week at the company's San Francisco headquarters.

Employees say morale is in steep decline, with Zynga forced this month to slash its 2012 results outlook for the second time.

Since going public at $10 a share, Zynga has lost over three-quarters of its market value. It has been hit by delays in its game pipeline as older titles fade, while it has struggled to come up with new hits for mobile devices.

Tuesday's layoffs amounted to roughly 150 out of Zynga's 2,900 workers.

Pincus said on Wednesday the company's management did not make the decision to cut employees "lightly" and that it recognized the "impact to our colleagues and friends."

But with the company's top line stagnant, analysts warned they expected news of further cuts on Wednesday's earnings call.

"They probably need to cut more people, and they probably will," said Michael Pachter of Wedbush Securities.

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Source: http://bottomline.nbcnews.com/_news/2012/10/24/14666666-zynga-lays-off-5-of-its-work-force-ending-13-games?lite

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Wednesday, October 24, 2012

Clothing Swap Startup Tradesy Wants To Turn Every Woman?s Closet Into Currency

TradesyThe average woman has worn just 20% of her wardrobe in the last year, but continues to spend upwards of $6,000 year on new clothing and accessories, leaving many (including me) with a closet full of extra clothing. So the idea that you could start making money off of your unwanted clothes is compelling for many women. Today LA-based Tradesy is hoping to solve this problem by launching a peer-to-peer marketplace that allows women to trade clothes.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/56klmNh2yxM/

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Video: Rapinoe on gold, next U.S. coach

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Source: http://nbcsports.msnbc.com/id/21134540/vp/49527783#49527783

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Monday, October 22, 2012

Family spokesman: George McGovern dead at age 90

SIOUX FALLS, S.D. (AP) ? George S. McGovern, a proud liberal who argued fervently against the Vietnam War as a senator from South Dakota and suffered one of the most crushing defeats in presidential election history against Richard Nixon in 1972, died before dawn Sunday. He was 90.

A spokesman for McGovern's family, Steve Hildebrand, told The Associated Press by telephone that McGovern died at 5:15 a.m. Sunday at a hospice in Sioux Falls, surrounded by family and lifelong friends.

"We are blessed to know that our father lived a long, successful and productive life advocating for the hungry, being a progressive voice for millions and fighting for peace. He continued giving speeches, writing and advising all the way up to and past his 90th birthday, which he celebrated this summer," a family statement released by Hildebrand said.

A decorated World War II bomber pilot, McGovern said he learned to hate war by waging it. In his disastrous race against Nixon, he promised to end the conflict in Vietnam and cut defense spending by billions of dollars. He helped create the Food for Peace program and spent much of his career believing the United States should be more accommodating to the former Soviet Union.

Never a showman, he made his case with a style as plain as the prairies where he grew up, often sounding more like the Methodist minister he'd once studied to be than a longtime U.S. senator and three-time candidate for president.

And McGovern never shied from the word "liberal," even as other Democrats blanched at the label and Republicans used it as an epithet.

"I am a liberal and always have been," McGovern said in 2001. "Just not the wild-eyed character the Republicans made me out to be."

Americans voting for president in 1972 were aware of the Watergate break-in, but the most damaging details of Nixon's involvement wouldn't emerge until after Election Day. McGovern tried to make a campaign issue out of the bungled attempt to wiretap the offices of the Democratic National Committee, and he called Nixon the most corrupt president in history, but the issue could not eclipse the embarrassing missteps of his own campaign.

McGovern was tortured by the selection of Missouri Sen. Thomas F. Eagleton as the vice presidential nominee, and 18 days later, following the disclosure that Eagleton had undergone electroshock therapy for depression, the decision to drop him from the ticket despite having pledged to back him "1,000 percent."

It was at once the most memorable and the most damaging line of his campaign, and called "possibly the most single damaging faux pas ever made by a presidential candidate" by the late political writer Theodore H. White.

After a hard day's campaigning ? Nixon did virtually none ? McGovern would complain to those around him that nobody was paying attention. With R. Sargent Shriver as his running mate, he went on to carry only Massachusetts and the District of Columbia, winning just 38 percent of the popular vote.

"Tom and I ran into a little snag back in 1972 that in the light of my much advanced wisdom today, I think was vastly exaggerated," McGovern said at an event with Eagleton in 2005. Noting that Nixon and his running mate, Spiro Agnew, would both ultimately resign, he joked, "If we had run in '74 instead of '72, it would have been a piece of cake."

McGovern's campaign, nevertheless, left a lasting imprint on American politics. Determined not to make the same mistake, presidential nominees have since interviewed and intensely investigated their choices for vice president. Former President Bill Clinton got his start in politics when he signed on as a campaign worker for McGovern and is among the legion of Democrats who credit him with inspiring them to public service.

"I believe no other presidential candidate ever has had such an enduring impact in defeat," Clinton said in 2006 at the dedication of McGovern's library in Mitchell, S.D. "Senator, the fires you lit then still burn in countless hearts."

George Stanley McGovern was born on July 19, 1922, in the small farm town of Avon, S.D, the son of a Methodist pastor. He was raised in Mitchell, shy and quiet until he was recruited for the high school debate team and found his niche. He enrolled at Dakota Wesleyan University in his hometown and, already a private pilot, volunteered for the Army Air Force soon after the Japanese attack on Pearl Harbor.

The Army didn't have enough airfields or training planes to take him until 1943. He married his wife, Eleanor Stegeberg, and arrived in Italy the next year. That would be his base for the 35 missions he flew in the B-24 Liberator christened the "Dakota Queen" after his new bride.

In a December 1944 bombing raid on the Cezch city of Pilsen, McGovern's plane was hit by anti-aircraft fire that disabled one engine and set fire to another. He nursed the B-24 back to a British airfield on an island in the Adriatic Sea, earning the Distinguished Flying Cross. On his final mission, his plane was hit several times, but he managed to get it back safety ? one of the actions for which he received the Air Medal.

McGovern returned to Mitchell and graduated from Dakota Wesleyan after the war's end, and after a year of divinity school, switched to the study of history and political science at Northwestern University. He earned his masters and doctoral degrees, returned to Dakota Wesleyan to teach history and government, and switched from his family's Republican roots to the Democratic Party.

"I think it was my study of history that convinced me that the Democratic Party was more on the side of the average American," he said.

In the early 1950s, Democrats held no major offices in South Dakota and only a handful of legislative seats. McGovern, who had gotten into Democratic politics as a campaign volunteer, left teaching in 1953 to become executive secretary of the South Dakota Democratic Party. Three years later, he won an upset election to the House; he served two terms and left to run for Senate.

Challenging conservative Republican Sen. Karl Mundt in 1960, he lost what he called his "worst campaign." He said later that he'd hated Mundt so much that he'd lost his sense of balance.

President John F. Kennedy named McGovern head of the Food for Peace program, which sends U.S. commodities to deprived areas around the world. He made a second Senate bid in 1962, unseating Sen. Joe Bottum by just 597 votes. He was the first Democrat elected to the U.S. Senate from South Dakota since 1930.

In his first year in office, McGovern took to the Senate floor to say that the Vietnam War was a trap that would haunt the United States ? a speech that drew little notice. He voted the following August in favor of the Gulf of Tonkin resolution under which President Lyndon B. Johnson escalated the U.S. war in the southeast Asian nation.

While McGovern continued to vote to pay for the war, he did so while speaking against it. As the war escalated, so did his opposition. Late in 1969, McGovern called for a cease-fire in Vietnam and the withdrawal of all U.S. troops within a year. He later co-sponsored a Senate amendment to cut off appropriations for the war by the end of 1971. It failed, but not before McGovern had taken the floor to declare "this chamber reeks of blood" and to demand an end to "this damnable war."

McGovern first sought the Democratic presidential nomination late in the 1968 campaign, saying he would take up the cause of the assassinated Sen. Robert F. Kennedy. He finished far behind Vice President Hubert H. Humphrey, who won the nomination, and Minnesota Sen. Eugene McCarthy, who had led the anti-war challenge to Johnson in the primaries earlier in the year. McGovern later called his bid an "anti-organization" effort against the Humphrey steamroller.

"At least I have precluded the possibility of peaking too early," McGovern quipped at the time.

The following year, McGovern led a Democratic Party reform commission that shifted to voters' power that had been wielded by party leaders and bosses at the national conventions. The result was the system of presidential primary elections and caucuses that now selects the Democratic and Republican presidential nominees.

In 1972, McGovern ran under the rules he had helped write. Initially considered a longshot against Sen. Edmund S. Muskie of Maine, McGovern built a bottom-up campaign organization and went to the Democratic national convention in command. He was the first candidate to gain a nominating majority in the primaries before the convention.

It was a meeting filled with intramural wrangling and speeches that verged on filibusters. By the time McGovern delivered his climactic speech accepting the nomination, it was 2:48 a.m., and with most of America asleep, he lost his last and best chance to make his case to a nationwide audience.

McGovern did not know before selecting Eagleton of his running mate's mental health woes, and after dropping him from the ticket, struggled to find a replacement. Several Democrats said no, and a joke made the rounds that there was a signup sheet in the Senate cloakroom. Shriver, a member of the Kennedy family, finally agreed.

The campaign limped into the fall on a platform advocating withdrawal from Vietnam in exchange for the release of POWs, cutting defense spending by a third and establishing an income floor for all Americans. McGovern had dropped an early proposal to give every American $1,000 a year, but the Republicans continued to ridicule it as "the demogrant." They painted McGovern as an extreme leftist and Democrats as the party of "amnesty, abortion and acid."

While McGovern said little about his decorated service in World War II, Republicans depicted him as a weak peace activist. At one point, McGovern was forced to defend himself against assertions he had shirked combat.

He'd had enough when a young man at the airport fence in Battle Creek, Mich., taunted that Nixon would clobber him. McGovern leaned in and said quietly: "I've got a secret for you. Kiss my ass." A conservative Senate colleague later told McGovern it was his best line of the campaign.

Defeated by Nixon, McGovern returned to the Senate and pressed there to end the Vietnam war while championing agriculture, anti-hunger and food stamp programs in the United States and food programs abroad. He won re-election to the Senate in 1974, by which point he could make wry jokes about his presidential defeat.

"For many years, I wanted to run for the presidency in the worst possible way ? and last year, I sure did," he told a formal press dinner in Washington.

Defeated in his bid for a fourth Senate term in the 1980 Republican landslide that made Ronald Reagan president, McGovern went on to teach and lecture at universities, and found a liberal political action committee. He made a longshot bid in the 1984 presidential race with a call to end U.S. military involvement in Lebanon and Central America and open arms talks with the Soviets. Former Vice President Walter Mondale won the Democratic nomination and went on to lose to President Ronald Reagan by an even bigger margin in electoral votes than had McGovern to Nixon.

He talked of running a final time for president in 1992, but decided it was time for somebody younger and with fewer political scars.

After his career in office ended, McGovern served as U.S. ambassador to the Rome-based United Nation's food agencies from 1998 to 2001 and spent his later years working to feed needy children around the world. He and former Republican Sen. Bob Dole collaborated to create an international food for education and child nutrition program, for which they shared the 2008 World Food Prize.

"I want to live long enough to see all of the 300 million school-age kids around the world who are not being fed be given a good nutritional lunch every day," McGovern said in 2006.

His opposition to armed conflict remained a constant long after he retired. Shortly before Iowa's caucuses in 2004, McGovern endorsed retired Gen. Wesley Clark, and compared his own opposition to the Vietnam War to Clark's criticism of President George W. Bush's decision to wage war in Iraq. One of the 10 books McGovern wrote was 2006's "Out of Iraq: A Practical Plan for Withdrawal Now," written with William R. Polk.

In early 2002, George and Eleanor McGovern returned to Mitchell, where they helped raise money for a library bearing their names. Eleanor McGovern died there in 2007 at age 85; they had been married 64 years, and had four daughters and a son.

"I don't know what kind of president I would have been, but Eleanor would have been a great first lady," he said after his wife's death in 2007.

One of their daughters, Teresa, was found dead in a Madison, Wis., snowdrift in 1994 after battling alcoholism for years. He recounted her struggle in his 1996 book "Terry," and described the writing of it as "the most painful undertaking in my life." It was briefly a best seller and he used the proceeds to help set up a treatment center for victims of alcoholism and mental illness in Madison.

Before the 2008 presidential campaign, McGovern endorsed Sen. Hillary Clinton for the Democratic nomination but switched to Barack Obama that May. He called the future president "a moderate," cautious in his ways, who wouldn't waste money or do "anything reckless."

"I think Barack will emerge as one of our great ones," he said in a 2009 interview with The Associated Press. "It will be a victory for moderate liberalism."

___

Online:

McGovern Center for Leadership and Public Service: http://www.mcgoverncenter.com

___

EDITOR'S NOTE ? Walter R. Mears, who reported on government and politics for The Associated Press in Washington for 40 years, covered George McGovern in the Senate and in his 1972 presidential campaign.

Source: http://news.yahoo.com/family-spokesman-george-mcgovern-dead-age-90-112752136--politics.html

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Argentine leader orders evacuation of ship seized in Ghana

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"iPad mini" appears in Apple Online Store suggested search results, but...

"iPad mini" is currently showing up as a suggested search result in Apple's online store. But so is "iPad air". And "iPad nano". And "iPad little". And more.

Search results from Apple.com have previously identified accurate product names, including the iPhone 5, but past behavior isn't always an indicator of future behavior. Maybe it's just an anomaly in Apple's database. Or maybe, just like iOS firmware strings have been found for iPhone 10,1, maybe someone on Apple's team is having a little fun this weekend.

The hilarity should end on October 23 at the iPad mini event. Until then, enjoy our iPad mini redux preview, and the screens below. Let me know if you find any other good ones.



Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/eHGB4_A_TmE/story01.htm

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Internet Search Marketing ? It's Much More Than You Can Think ...

Internet marketing is like the oxygen your website needs to sustain and breathe. Marketing on web is not a choice you need to make, but it?s a necessity you need to fulfill. Especially when the consumers of today are increasingly getting conscious about online businesses, saying no to this marketing strategy is like doing a major harm to your business?s well being.

Like Web marketing, effective internet search marketing is a sophisticated and result-oriented process. With more than 80% consumer?s first surfing search engines for any new query, why do you wish to stay back on just this podium? Now, get ready to partner with an ace internet marketing service provider who with their team of Web marketing manager, lead by internet marketing director can offer your business the ideal solution.

Internet marketing companies are indulged in offering a diverse range of Online marketing consultants. All experts in their respective field can help in easily devising a marketing plan that can actually work in practical. Relying on foolproof planning and execution, pros at such firms do not believe in shortcuts and offer solutions that although time consuming but are assured ways to succeed online.

The benefits one can reap when practicing Web marketing are many, some that are most common include:

  • Online marketing has the highest ROI in comparison to any other marketing channel.
  • More than 80% of users first surf the web while searching for any new product or service.
  • With apt strategies in internet search marketing, your business can easily get found when someone searches for your products and services, which traditional marketing cannot offer.
  • With online marketing you can easily target specific audiences against an amount that is acceptable and moreover affordable.
  • Marketing on web is not a fashion, but a style that will remain functional always and this will keep getting better and popular even in the unforeseeable future.
  • Another advantage is email marketing that can help you stay in touch directly with your consumers and can assist you in sending message to consumers anytime of the day, helping them stay informed and updated.
  • With web marketing you get complete freedom to test different expressions and strategies without spending a fortune to finally know, which can work best. This is something which print advertising does not allow you to experience.

So, why wait more? Partner with an internet marketing service provider to know what your business has been missing until now. With Web marketing managers at such firms you cannot just locate your consumers, but can even lure them to get indulged.

From best in web marketing to internet search marketing, you can have it all easily and quickly accomplished for your firm with experts at internet marketing companies.

So, what more do you want? Get ready to get in touch with people who can actually make a difference in your Business?s ROI. With easily accessible tools and a great podium all just a click away, acquiring success that is long lasting is no more a task too hard to accomplish.

Source: http://sbrexec.com/2012/10/internet-search-marketing-its-much-more-than-you-can-think/

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Monday, October 15, 2012

Here?s To The Death Of ?Personal Branding? On The Internet

306292184_640I'm not exactly sure who made being a "personal brand" a thing on the Internet, but I'd really like to sit down with them and ask them why they thought that it was a good idea. You see, an entire ecosystem of people looking to make money have cropped up around this notion of helping people become a "brand." Honestly, it's bull, and I'd like to see it stop. Why is it bull? Because unless you're Kim Kardashian and have a line of clothes of fragrances, you are not a brand. You are a person.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/XUIs8PrpZ1Y/

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Microsoft turns on new Xbox music service

Xbox Music launches this week.(Photo: Microsoft)

Story Highlights

  • Free streaming of tracks from 18 million-song library
  • $9.99 monthly service has cloud storage and no ads
  • Individual tracks to cost 99 cents to $1.29

12:01AM EDT October 15. 2012 - Microsoft is pushing the play button on a new music initiative to take on iTunes and streaming services, such as Spotify.

Under the umbrella of Xbox Music, Microsoft will launch a streaming service, that is free on Windows 8 PCs and tablets, a music subscription service and a pay-as-you-go music store that sells individual tracks and albums.

Microsoft's music play coincides with the Oct. 26 launch of its Windows 8 operating system for computers and Windows RT for tablets and the arrival of new Windows phones later this fall.

As the service expands over the coming weeks ? from the Xbox 360 to Windows 8 and Windows Phone 8 ? its cloud-based connectivity will allow access to playlists and music collections across devices. "We went from saying, 'Let's not do a device-specific thing, (to) let's really create an all-in-one solution," says Jerry Johnson, Microsoft's general manager for Xbox Music.

Despite Microsoft's attempts with its Zune devices and music player and, before that, MSN Music, Apple remains dominant in digital music sales. In the second quarter of 2012, Apple accounted for 64% of digital music sales, according to market research firm NPD Group. Apple also sells nearly one-third (29%) of all music, digital or physical. While Amazon commands 16% of the digital market, Microsoft and others, including Google Play, had market shares of 5% or lower, NPD says.

Digital music sales are expected to increase 10% this year, NPD estimates, while interest in streaming and on-demand music is on the rise.

ITunes, Internet radio services such as Pandora, and on-demand music purveyors such as Spotify all are "strong players," says Johnson, but none represents a one-stop musical shop. Integration of music across Windows devices, he says, "really solves a consumer problem that exists out there."

When Xbox Music hits the Xbox 360 video game console Tuesday as part of an overall system update, users can apply for a free 30-day trial of Xbox Music Pass (after that it's $9.99 monthly). That will give them access to on-demand streaming playback of a library of 18 million songs in the U.S. That's comparable to streaming services such as Spotify, Rdio and MOG, which top out at about 18 million.

Owners of computers and tablets upgraded to Windows 8 ? and new Windows 8 device purchasers ? will have an ad-supported free Xbox Music streaming on-demand program on board. Upgrading to the $9.99 monthly service allows ad-free streaming across devices and offline play.

Playlists and music bought through the new Xbox Music store, which launches on PCs and tablets Oct. 26 (tracks cost 99 cents to $1.29), are also stored in a cloud-based music locker. The store will also be found on new Windows phones.

Also hitting that day (Oct. 26) is Microsoft's Smartglass app that lets you move music from Windows computers, tablets and phones to the Xbox 360 to see on the TV and hear on a home stereo. The tablet then offers a second screen experience with artist information, art, photos, lyrics and related artists. Microsoft plans to develop music apps for iOS and Android devices, too.

Establishing Xbox as its entertainment brand is a good move for Microsoft because in the past "it has been all over the place," says Michael Gartenberg of tech research firm Gartner.

The free streaming service that appears on Windows 8 computers and tablets is "a way for Microsoft to break into the music market in a way that consumers understand," he says. "Once you have someone using the service, you have a better chance of getting them into the subscription services and buying music from there. This looks like a pretty complete and thought-out service that encompasses the entire Microsoft ecosystem."

Source: http://rssfeeds.usatoday.com/~r/usatoday-TechTopStories/~3/eVMNp_D0lpA/

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Sunday, October 14, 2012

Egypt's liberals, Islamists clash, 110 reported injured

CAIRO (Reuters) - Opponents and supporters of Egyptian President Mohamed Mursi clashed in Cairo on Friday in the first street violence between rival factions since the Islamist leader took office.

Islamists and their opponents threw stones, bottles and petrol bombs, and some fought hand-to-hand, showing how feelings still run high between the rival groups trying to shape the new Egypt after decades of autocracy, although the streets have generally been calmer since Mursi's election in June.

The Health Ministry said 110 people had sustained light to moderate injuries, state media reported.

A government is in place, but Islamists and liberals are at loggerheads over the drafting of the new constitution, which must be agreed before a new parliament can be elected.

Many of the thousands who gathered in Tahrir Square were angry at this week's court ruling that acquitted former officials charged with ordering a camel-and-horseback charge on protesters in the uprising that ousted Hosni Mubarak last year.

But even before that ruling, Mursi's opponents had called for protests against what they say is his failure to deliver on his promises for his first 100 days in office.

"Down, down with rule by the guide!" Mursi's opponents chanted, suggesting that Muslim Brotherhood leader Mohamed Badie pulls the strings even though Mursi officially quit the Brotherhood on taking office.

"Mursi! Mursi!" the president's backers responded.

Late on Friday, a statement issued by the cabinet condemned the events saying they hinder the government's political and economic efforts. It said Prime Minister Hisham Kandil "calls on all parties present in Tahrir Square and the other squares and places to stay away from any action that would tarnish the image of new Egypt".

BUSES SET ON FIRE

Some demonstrators pulled down a temporary podium that had been erected on a side of the square for speeches. Later, Islamists took over the square, triggering scuffles in nearby streets as they tried to keep rival groups out.

Two buses parked near the square were set alight. Witnesses said they had been used by the Brotherhood to bring in supporters.

The Brotherhood's Freedom and Justice Party (FJP) in a statement expressed its "sorrow" over what happened to the buses it said were used to bring members to Cairo. It also condemned an attack on the Brotherhood's headquarters in the industrial city of El-Mahalla El-Kubra.

"We went to protest against the constituent assembly and Mursi's failure in his 100 days, and Islamists prevented us and are now controlling the square," said Islam Wagdy, 19, a member of a group set up by leftist politician Hamdeen Sabahy.

An FJP spokesman denied this. "What happened today was an attempt by the liberal powers ... to prevent Islamists expressing their views and protesting in Tahrir, which belongs to all Egyptians and not to a certain current," Ahmed Sobeih said.

There was no intervention by police, who have often been the target of protesters' anger because of their brutality against demonstrators in last year's revolt.

The Brotherhood, which joined Friday's protest, had said it should focus on this week's court ruling.

The charge by men on camels and horseback was one of the most violent incidents of the uprising that ousted Mubarak in February 2011. The case has been closely watched by those seeking justice for the hundreds killed in the revolt.

The court acquitted top Mubarak-era officials such as former lower house speaker Fathi Sorour and Mubarak aide Safwat Sherif, both of whom are scorned by many Egyptians.

ALEXANDRIA

Demonstrators also gathered in Egypt's second city, Alexandria, where Mursi went to a mosque to perform Friday prayers before giving a speech.

"We won't let anyone involved in corruption get away," he said, while urging protesters not to disrupt workers. As he spoke, some chanted: "The people want the judiciary purged."

Many blame the general prosecutor, perceived as a Mubarak loyalist, for not securing convictions.

In an apparent bid to appease the public, the president had said late on Thursday he was moving Abdel Maguid Mahmoud out of that position to make him ambassador to the Vatican, because Egyptian law prevented him being dismissed.

Mahmoud denounced the move and told Egyptian media he would stay on. The influential judges' club condemned the decision as interference and called for a meeting of judicial officials on Sunday to discuss action, the state news agency reported.

Even some political groups who wanted Mahmoud out questioned the way Mursi had done it. The liberal Free Egyptians Party said changing the prosecutor should be an independent judicial move.

Mursi has won grudging respect from some opponents for pushing the army out of politics, after decades of rule by military men, and for raising Egypt's profile abroad.

But many Egyptians, with high expectations after the revolt, say he has not done enough at home, failing to deliver on promises for his first 100 days such as cleaning up cities and getting traffic moving in Egypt's congested streets.

Many more secular-minded Egyptians and minority Christians also worry that Mursi and his Islamist supporters will seek to impose religious restrictions on society.

Source: http://news.yahoo.com/egypts-liberals-islamists-clash-110-reported-injured-090038268.html

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Saturday, October 13, 2012

How To Get A Deal On A Commercial Property | Eric Chua : Life - First

Being a commercial property owner is exciting, however, it can also be quite an undertaking when trying to manage the property. All this can really make you confused about where exactly to get started so that you can make certain all your bases are covered. Trying to figure out everything you need to know about owning commercial property can be difficult, but this article can get you started into acquiring and owning a commercial property.

You can find different kinds of brokers. There are agents who only represent tenants and there are full-service brokers who work with both tenants and landlords. You may benefit significantly better from hiring the services of a broker working with tenants exclusively, as he has significantly more experience representing tenants successfully.

The key terms will include the pro forma and the rent roll. If you fail to check out the terms, you might find something that is at odds with the rent roll and make the pro forma unreliable.

TIP! Double-check that you are seeking a realistic amount of money for your property. Your property?s actual value is influenced by many factors.

Make sure the property you are interested in has access to utilities. Look for access to water, electricity, gas an a sewer or anything specific to what you intend to use this property for.

Always check the credentials of the inspectors you hire. Pay particular attention to the credentials of any pest-control experts because many of them are not licensed. Reviewing credentials will help you prevent major issues after you make the purchase.

You should acquire tour site checklists when you?re examining several properties. Make sure to advise the property owners when you want to take the next step past the first proposal responses. Don?t be shy about telling the owners that you are thinking about purchasing another property. This may ensure that you get a much more viable deal.

TIP! Before you begin seeking commercial real estate property, be sure to identify your requirements. Identify which features in a commercial property are high value to you, and make a list.

Don?t be led by hype and fads when searching for commercial real estate. Do not be hasty about making a investment decision. You will be full of regrets if you are stuck with a property that is not what you expected. Realize that it can sometimes take at least one year for the proper investment opportunity to present itself.

For those who have an interest in real estate, reference websites that offer information to a investors of all experience levels. No one can ever honestly claim that they know too much.

Have family, friends, and professional lenders partner with you to make sure you have enough cash to buy commercial real estate. Two repayment options for these loans are traditional repayments, in which you repay the loan at a certain interest rate, or a profit-based repayment, in which the lender receives some of the proceeds from the property?s income.

TIP! You need to be able to spot good deals to be able to make them advantageous to you. People who deal in real estate on a professional level can spot a great deal immediately.

When you are shopping around for commercial property, try to buy properties that are bigger on average. This lets you take advantage of economies of scale. There is a fixed cost associated with buying a building, plus a smaller marginal cost per unit, so the more units a building has, the lower the cost will be per unit.

You will be a successful investor if you spend enough time and work hard enough to find the best deal possible and get your property ready. You need to stay diligent at buying commercial real estate. If you remember the tips you have learned from this article, you will soon own the ideal commercial property for your

Source: http://www.maynaseric.com/how-to-get-a-deal-on-a-commercial-property

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Can You Believe It? How TV Portrays Love ? For Your Marriage

October 12, 2012

Can unrealistic portrayals of romantic relationships on television ? in dramas, reality shows, movies and other programming ? result in harm for some married couples?

Quite possibly yes, according to Jeremy Osborn, an assistant professor in the communications department at Albion College in south-central Michigan. But it seems the big problem here is a belief problem ? belief on the viewer?s part that television?s frequently skewed images of romantic relationships are, instead, more or less on target.

Osborn?s work suggests that people do their marriages no favor in imagining on some level that these kinds of TV portrayals are consistent with love in real life.

?I found that people who believe the unrealistic portrayals on TV are actually less committed to their spouses and think their alternatives to their spouse are relatively attractive,? said Osborn.

?The exciting escapades of highly attractive, young TV couples present an impossible ideal, and they also lead people to believe there is an endless supply of attractive partners just waiting around every corner,? Osborn told me.

He said, ?Those kinds of images and distortions can be problematic if you buy into them.?

Osborn reported on his study of 392 married individuals in an article titled ?When TV and Marriage Meet? that appears in the September edition of Mass Communication and Society.

The results of his investigations ?suggest that people who watch more romantically themed programming? and especially people who invest belief in the portrayals offered by this programming are less committed to their marriages, even when they are not all that dissatisfied in their marriages.

Moreover, these people may perceive the ?alternatives? to their current relationship more favorably and consider their marriages ?more costly? in terms either of their partner?s unattractive qualities or, for example, the loss of time.

Personal Expectations

A ?take-home point? of Osborn?s study is that people need ?to stop and think about what their expectations are for their spouse and marriage, and where those expectations came from,? he explained. He might ask a person, ?How high is the bar you have set??

If one spouse judges the other ?against a standard set by TV or movies, that is a problem,? Osborn said. Similarly, if decisions are made ?about appropriate behaviors in [a] marriage based on those standards, that could be a problem.?

I asked Osborn about his findings related to belief in TV depictions of romantic love. My suspicion, I told him, is that few if any of my relatives, friends or colleagues believe that TV programming tends to present romantic love accurately.

In response, Osborn made clear that the level of belief in these TV messages may indeed vary from person to person. But he found that ?as belief scores went up? among the participants in his study, ?commitment scores went down.?

Most people in Osborn?s study did not report ?that they believed heavily in the portrayals? of love on television, he said. ?However, the more they did, the lower their commitment scores were.?

He considered this observation important ?because it highlights the fact that you don?t have to be an ardent believer? in these portrayals ?to be affected.? He added, ?Merely believing in them more than the next person predicts that you will report being less committed.?

At the same time, Osborn has acknowledged that participants in his study who already felt less committed to their marriages might have tended to express more belief ?for some reason? in TV depictions of romance. More research is needed into the causal connections here, he said.

TV and Viewer Interactions

Osborn clearly hoped with his study not only to broaden understanding of ?the role of television in the relational outcomes of people in long-term, committed relationships,? but to prompt reflection on this.

Along with others in the communications field, Osborn wonders how people are influenced in their actual relationships by their TV viewing. Most researchers hold that television ?presents a distorted view of romantic relationships,? his study notes.

But what I found particularly interesting about this study was its apparent suggestion that reflection on these issues should not be confined solely to what television brings ?to? us, so to speak. We also need to assess the beliefs that we bring to television ? to take stock of how we interact with television.

Osborn?s study observes that ?for better or worse,? television ?occupies a central place in our lives,? with viewers spending ?a considerable portion of each day escaping from the ?real world? by immersing themselves in the ?television world.??

The society we inhabit ?perpetually immerses itself in media images from both TV and the web, but most people have no sense of the ways those images are impacting them,? Osborn commented.

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Source: http://foryourmarriage.org/can-you-believe-it-how-tv-portrays-love/

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Clinton reaffirms support for Libya, Arab democracy

Yuri Gripas / REUTERS

U.S. Secretary of State Hillary Clinton delivers a keynote address on "U.S. Strategic Engagement with North Africa in an Era of Change" at the Center for Strategic & International Studies in Washington on Friday.

By Catherine Chomiak, NBC News

A month after the terrorist attack on the U.S. mission in Benghazi, Libya, that killed four Americans, including Ambassador Chris Stevens, Secretary of State Hillary Clinton reaffirmed the United States' support for the new governments emerging from the Arab Spring.

Speaking at the Center for Strategic and International Studies on Friday, Clinton said the attack in Benghazi and the burning of the American School in Tunis have led some to question the promise and hope of the Arab Spring. She said she has always been clear-eyed about the challenges that were ahead.??

"Let me start by stating the obvious: Nobody should have ever thought this would be an easy road. I certainly didn't," Clinton said.?

Romney: Biden 'doubling down on denial' in explanation of Libya response

She went on to say that the United States "will not pull back our support for emerging democracies when the going gets rough. That would be a costly strategic mistake that would, I believe, undermine both our interests and our values." ??


Clinton described what occurred on Sept. 11 in Benghazi as a ?terrorist attack? and said she appointed a review board to examine the security procedures in Benghazi. The U.S. government is "sparing no effort" to track down the terrorists responsible for the attack, Clinton said.

The terrorists who attacked the mission do not represent the Libyan people, she added, citing the protests against the militias there.

"The United States will not retreat," Clinton said. "We will keep leading and we will stay engaged in the Maghreb and everywhere in the world, including in those hard places where America?s interests and values are at stake."

The United States is "stepping up" its counterterrorism efforts in northern Mali, Clinton said, where al-Qaida in the Islamic Maghreb is trying to expand its reach.?

"For some time, al-Qaida in the Islamic Maghreb and other terrorist groups have launched attacks and kidnappings from northern Mali into neighboring countries. Now, with the chaos and ethnic conflict there allowing these groups to carve out a larger safe haven, they are seeking to extend their reach and their networks in multiple directions," she said.

More world stories from NBC News:

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Source: http://worldnews.nbcnews.com/_news/2012/10/12/14398947-clinton-reaffirms-support-for-libya-emerging-democracies?lite

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Cells control energy metabolism via hedgehog signalling pathway

ScienceDaily (Oct. 12, 2012) ? Cancer, diabetes, and excess body weight have one thing in common: they alter cellular metabolism. Scientists from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg and the Medical University of Vienna together with an international research team have jointly resolved a new molecular circuit controlling cellular metabolism. The previously unknown signalling pathway, acting downstream of the hedgehog protein enables muscle cells and brown fat cells to absorb sugars without relying on insulin. Substances that selectively activate the signalling pathway could thus be utilized in the treatment of diabetes and obesity. With their results, the researchers are also able to explain why various new anti-cancer agents have induced mysterious pronounced side effects in the clinics.

Hedgehog was initially identified as an important protein for embryonic development across various organisms. Without hedgehog, the physiological partitions of the embryo become indistinct. However, hedgehog also influences replication, migration and specialisation of cells ? that is, the processes that also play a role in carcinogenesis. Mutation of genes also occurs concomitantly in various types of cancer, such as pancreatic, gastric or intestinal carcinomas. Above and beyond this, hedgehog inhibits the formation of ?bad? white adipose tissue. Brown or ?good? fat that serves to control body temperature, however, remains unaffected.

Hedgehog is therefore a very promising target for medications that fight cancer, diabetes and excess body weight. The US Food and Drug Administration (FDA) approved the first hedgehog inhibitor, Vismodegib, for treatment of cancer this year. There are presently at least six further agents being tested in clinical studies. Surprisingly, the first patient cohorts receiving Vismodegib have shown serious side effects, such as weight loss and muscle cramps, to the extent that more than half of the participants in the studies had to discontinue use.

The new research results appear to explain the mysterious cramps and suggest an easy, safe and already available adjunct therapy to resolve the complication. The researchers discovered a new hedgehog signalling pathway that is independent of the activation of transcription factors and genes known thus far. Cells control their primary energy metabolism, including the glucose, fatty acid and amino acid metabolisms, via this pathway.

The membrane protein known as Smo plays an important role here. Smo controls the known signalling pathway through transcription factors, as well as the new pathway via a much faster AMP-kinase enzyme and calcium dependent pathway. Smo is activated if hedgehog binds to a specialised receptor in the cell membrane. In the signalling pathway that has now been discovered, calcium flows through the membrane channels into the cell and activates calcium-dependent enzymes that in turn activate the AMP-kinase. This completely rewires metabolism. The cell can rapidly absorb large quantities of glucose using the AMP-kinase and other enzymes, rebalancing anabolism and catabolism. Further, rather promoting efficient energy metabolism through mitochondria, the new hedgehog signalling pathway prompts much less efficient via lactic acid fermentation ? a process with which cancer cells use to acquire their energy without oxygen, for example (Warburg effect).

Even more surprising, the new pathway is stimulated promiscuously by both classical activators and inhibitors of the old, ?canonical? hedgehog pathway. This finding potentially flips the interpretation of tens, if not hundreds of research papers in the field. Still not clear, this could be one additional reason why hedgehog inhibitors are so effective, in essence they starve the cancer cells from the inside.

Counterintuitive inhibitor-based activation of the hedgehog and Smo-calcium/AMP-kinase signalling pathways interferes with anabolic metabolism. ?Activation of the AMP-kinase and increased catabolism could explain the exaggerated weight loss of the participants in the clinical studies. More importantly though, the influx of calcium into muscle cells leads to instant contraction, and must be triggering the cramps,? explains Andrew Pospisilik from the Max Planck Institute in Freiburg. Importantly, Hedgehog inhibitors do not have to lead to these side effects. ?We targeted the Smo protein with various substances and found out that there are inhibitors that do not evoke an increase in calcium or glucose values, and critically, these same inhibitors fail to cause muscle cells to contract in culture. The development of medications such as these, which have minimal side effects, is therefore entirely possible," says Pospisilik.

In addition, again using fat cells, the scientists find that cells dramatically increase the glucose quantity they can absorb ? without relying on insulin. Glucose-tolerance tests on mice confirmed the findings. This was accomplished by administering a specific amount of glucose via the food and measuring the blood glucose concentration afterwards. Mice that had previously been treated with the classic hedgehog inhibitor cyclopamine had correspondingly lower blood glucose than untreated animals. Apparently, cyclopamine increases the glucose absorption, but only in the brown adipose tissue and various types of muscle tissue. Thus, researchers measured an increase in body temperature of around one degree ? a sign of higher activity in brown adipose tissue.

?Agents that only activate the Smo-calcium/AMP-kinase hedgehog signalling pathway are therefore candidates as medications for treating excess body weight, as well as type-1 and type-2 diabetes. Similar to the broad hedgehog inhibitors, they possess the potential to induce muscle cramps. Thanks to our findings, we now know that a new agent must first be tested on muscle cells before it is used on humans,? says Harald Esterbauer from the Medical University of Vienna.

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Story Source:

The above story is reprinted from materials provided by Max-Planck-Gesellschaft.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Raffaele Teperino, Sabine Amann, Martina Bayer, Sean?L. McGee, Andrea Loipetzberger, Timothy Connor, Carsten Jaeger, Bernd Kammerer, Lilli Winter, Gerhard Wiche, Kevin Dalgaard, Madhan Selvaraj, Michael Gaster, Robert?S. Lee-Young, Mark?A. Febbraio, Claude Knauf, Patrice?D. Cani, Fritz Aberger, Josef?M. Penninger, J.?Andrew Pospisilik, Harald Esterbauer. Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat. Cell, 2012; 151 (2): 414 DOI: 10.1016/j.cell.2012.09.021

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/eIXIjrK5kvE/121012112159.htm

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Australian Restaurant Removes Urinals Shaped Like Women's Mouths After Backlash

Given past controversies involving urinals in the shape of lipsticked, arguably female mouths, a restaurant in Sydney shouldn't have been surprised when its bathroom fixtures kicked up a certain amount of angst on the part of Aussie feminists.

Anne Summers, an Australian feminist, said the toilets were ?asking men to put their dicks in these mouths as urinals." She also accused the Ananas Bar and Brasserie of perpetuating misogyny.

Ananas, a new French restaurant in the city's upscale Rocks district, said the bright, kitschy urinals were "a commonly used European design piece," according to the AFP. However, the restaurants agreed to remove the offending pieces and issued an apology.

"We sincerely [apologize] if they have caused [offense]. They are being removed today," a spokeswoman said in a statement.

According to the Telegraph, Meredith Burgmann, another Australian feminist, referred to the urinals as "schoolboy grubbiness," but added their appearance at the restaurant was not surprising given the country's "outpouring of misogynist incidents."

Designed by Meike van Schijndel, of the firm "Bathroom Mania," similarly mouthy urinals have appeared all over the world, including in a German Rolling Stones museum and the house of reality star Khloe Kardashian, according to TMZ.

The urinals' popularity seems to be a double-edged sword for designers willing to brave the possible backlash. The pieces have certainly been met with their fair share of criticism ever since Virgin Airlines decided to pull the plug on plans to install the pieces in its JFK Airport clubhouse in 2004.

The Dutch artist has said the design is not supposed to be sexualized. "Lighten up," she told the New York Daily News in an email. "[It's] just a cartoonish looking mouth. There are worse things in the world to get all worked up about."

New York's chapter of the National Organization for Women (NOW) disagreed.

"There's something wrong with someone who thinks that urinating symbolically into the mouth of a woman is quirky and fun," NOW president Rita Haley said during a 2004 press conference. "It displays a horrendous lack of social consciousness," she said, according to the Daily News.

Earlier on HuffPost:

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Source: http://www.huffingtonpost.com/2012/10/11/australian-restaurant-ananas-removes-urinals-shaped-like-womens-mouths-misogyny_n_1958910.html

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The Biden-Ryan debate, and the art of not losing (Washington Post)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

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Friday, October 12, 2012

Stocks head higher, despite Europe worries

NEW YORK (AP) ? One piece of good news on jobs was enough Thursday on Wall Street.

The stock market popped higher after the Labor Department reported an encouraging decline in weekly claims for unemployment insurance. That one piece of good news was enough to help traders forget about a drumbeat of worrisome developments, like a widening U.S. trade deficit, higher unemployment in Greece and a ratings cut for Spain.'

The major stock indexes all rose, putting the market on track for its first up day this week. At midday, the Dow Jones industrial average was up 23 points to 13,368, a stark reversal from two straight days of triple-digit declines. The Standard & Poor's 500 was up five to 1,438. The Nasdaq composite index was up seven to 3,058.

That might seem puzzling. But maybe the market is so used to bad news that it's easy enough to shrug off ? particularly the S&P downgrades, which some investors don't place much faith in anyway. Or maybe people are looking for a reason to invest, anxious to meet year-end investment goals.

"If you look at bank reserves, personal balance sheets, business balance sheets, there's money on the sidelines that wants to get put to work," said Joe Costigan, director of equity research at Bryn Mawr Trust Company in Pennsylvania. "And I think that at the moment, any good news is drawing capital to it and we're now in the process of looking past the bad news."

Also fueling the stock market was a note from Citi analysts, upgrading U.S. stocks to the equivalent of buy. The analysts, led by Hasan Tevfik and Robert Buckland, argued that stocks are relatively cheap and that central banks seem likely to take more steps to try to boost the economy.

Still, their report wasn't all cheery. "Profits are slowing around the world," they wrote, "and (earnings-per-share) expectations need to be cut further, in our view."

Already this week, the aluminum manufacturer Alcoa kicked off the third-quarter earnings season with a disappointing loss. Thursday, shares of grocery store Safeway slipped 3 percent, losing 51 cents to $15.78, after it reported a lower profit margin. Restaurant chain Ruby Tuesday dipped 9 cents to $6.93 after reporting lower profit late Wednesday.

And that was on top of a stream of separate negative developments Thursday. Among them: The Commerce Department reported that foreign demand declined for American-made cars and farm goods. In Germany, economic researchers predicted the country's growth would slow, and warned that patience for bailing out weaker European countries was evaporating. Unemployment in Greece, one of the countries surviving on bailouts, hit a record high of just more than 25 percent. And the Standard & Poor's ratings agency late Wednesday cut its rating on Spain's debt to just one level above junk status.

In Tokyo, where the International Monetary Fund and the World Bank were meeting, IMF chief Christine Lagarde warned that the global economic recovery is weaker than many had expected. She called for urgent action to fix Europe's debt problems and an approaching fiscal crisis in the U.S.

Even the jobs news wasn't enough to persuade everyone. The Labor Department said that weekly applications for unemployment aid fell to their lowest level since February 2008, before the financial crisis. But the unemployment rate is still much higher than it was then ? 7.8 percent, compared with 4.9 percent in February 2008. The labor force participation rate is also lower, meaning some unemployed workers have simply given up looking for work, which can make the jobless numbers seem better than they really are.

One stock that made a big move up was Sprint Nextel. Shares soared 15 percent, rising 76 cents to $5.80, after a report that the company could be bought by Softbank, a Japanese cell phone provider.

Source: http://news.yahoo.com/stocks-head-higher-despite-europe-worries-140543249--business.html

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prudent investor newsletters: Despite Bankruptcy Case, ?Rich Dad ...

Popular author Robert Kiyosaki of ?Rich Dad Poor Dad? fame seems under assault from mainstream media. While it has been true that Mr.Kiyosaki has indeed filed for bankruptcy, the guy has been insinuated as personally ?bankrupt?.

In an ironic twist, the author of the bestselling financial help book ?Rich Dad Poor Dad,? Robert Kiyosaki, has filed for bankruptcy.

This after one of his companies lost a $24-million court judgment, according to a report from the New York Post.

?Kiyosaki?s Rich Global LLC filed for bankruptcy after being ordered to pay nearly $24 million to the Learning Annex and its founder and chairman, Bill Zanker,? the report said.

?US district judge Shira A. Scheindlin in April ordered Rich Global to pay up $23,687,957.21 after a jury ruled Kiyosaki must give the Learning Annex a percentage of his profits after using their platform for speaking engagements, including a 2002 gig at Madison Square Garden,? it added.

In reality, the reason behind Kiyosaki?s Rich Global LLC filing for bankruptcy has been about legal maneuvering

The same article quotes Mike Sullivan, chief executive officer of Kiyosaki?s Rich Dad Co as saying:

?Robert and [wife] Kim are not paying out of personal assets. We have a few million dollars in his company, but not 16 or 20. I can?t do anything about a $20-million judgment? We got hit for what we think is a completely outlandish figure.?

Mainstream media never explains this or at least gives an effort to make news objective or balanced.

Fundamentally, the case stems from charges of breach of contract by an aggrieved party whom was awarded in the court case.

But apparently the fame went to his head because according to court papers obtained by the Post, Kiyosaki, who published his first "Rich Dad" book in 1994, never paid the Annex its rightful share. Said founder and chairman Bill Zanker: "Oprah believed in him, and Will Smith believed in him, but he didn't keep his promise to us."

Yet Mr. Kiyosaki remains solvent in spite of the bankruptcy filing. Again from Business Insider:

Despite the blow to the personal finance guru's reputation, Kiyosaki probably won't feel the pinch in his wallet. Forbes pegs his net worth around a cool $80 million, and Kiyosaki, who's written 11 books, operates as many as ten other companies. Rich Global was said to be worth a few million when it went under.

Again, legal maneuvering from a bankruptcy procedure has been about the potential to discharge debts through the bankruptcy court.

According to bankrate.com, debts that are usually discharged from bankruptcy covers the following:

I think Mr. Kiyosaki?s decision to file for bankruptcy means that his case will fall under

Lawsuits and judgments: These result from creditors or collection agencies suing you for failing to pay. With few exceptions, you may eliminate the lawsuit even after it has begun or the judgment that results from the lawsuit.

So despite the bankruptcy proceedings and the implied media slur, Mr. Kiyosaki remains a RICH Dad!!! This serves as one neat example of why you shouldn't trust the mainstream media.

Source: http://prudentinvestornewsletters.blogspot.com/2012/10/despite-bankruptcy-case-rich-dad-poor.html

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Award-Winning Montessori Numbers Celebrates 10K App Sales ...

Categories: PRMac, | 0 comments |

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Sophia Antipolis, France ? Award-winning children?s app developer L?Escapadou today announces that Montessori Numbers, an innovative educational app for iPad, has been put on special offer and the price reduced by 66% ($0.99) for a limited time. This special offer is to celebrate 10K units sold since its August launch.

Montessori Numbers has won many accolades including:
* Children?s Technology Review: Editor?s Choice Award for Excellence in Design ? rated 4.8/5 ? ?This is a must-have app, for any early learning setting? ?
* NBC News : ?A fantastic app for helping the young students understand the relationship between numbers and the quantity they stand for?
* Featured by Apple as ?New and Noteworthy? (Education)
* Wired?s GeekDad Approved
* ?Montessori Numbers is among the best educational apps for young children I?ve seen. The pacing is very good and the verbal feedback is very supportive. ? Mary Ellin Logue, Ed.D, Early Childhood Education, University of Maine
* Rated 5 stars on Best Kids Apps and MindLeap
* Selected by KinderTown.com
* Golden App Award ? 5/5 ? Apps for Homeschooling

Montessori Numbers is designed to help build sound mathematical foundations in children aged 3-7 by using a concrete, visually significant material inspired from the Montessori methodology. Montessori Numbers focuses on numbers from 0-1000, and offers a sequence of guided activities that gradually help children reinforce their skills. Each activity offers several levels of increasing complexity.

Montessori Numbers supports the following activities:
* Experiment with quantities and learn their names
* Learn the numerals and their names
* Learn to count
* Associate quantities with numerals/numbers
* Understand the decimal system and place value
* Introduce addition and subtraction

Montessori Numbers builds on the iPad?s touch feature, and uses verbal feedback for more efficient learning. The app can pronounce any number between 0 and 1009 (American, British and Australian voices available).

Montessori Numbers Adheres to Common Core State Standards in the Following Domains:
* Counting and Cardinality (K.CC)
* Operations and Algebraic Thinking (K.OA, 1.OA.1/2/5)
* Number & Operations in Base Ten (K.BNT,1.NBT.1/2/4/5/6, 2.NBT.1/2/3/5/8/9, 3.NBT.1/2).

Device Requirements:
* Compatible with iPad
* iOS 4.2 or later
* 55 MB

Pricing and Availability:
Montessori Numbers 1.1 is priced $0.99 USD today only to celebrate the update. Regular price is $2.99 USD. It is available worldwide exclusively through the App Store in the Education category for iPad and iPhone. Journalists and bloggers interested in a promo code, further information, developer interviews or additional assets should contact L?Escapadou via email.

Montessori Numbers 1.1
Purchase and Download
YouTube Video 1
YouTube Video 2
Screenshot
Press Kit (zip)

L?Escapadou, founded in 2010, is an award-winning family design studio dedicated to creating educational and fun apps for iPad and iPhone and has been recognized as ?Editor?s Choice? by Moms With Apps. Montessori Crosswords and Word Wizard, L?Escapadou?s top selling apps, have won the Children?s Technology Review Editor?s Choice Award for Excellence in Design. Pierre Abel holds a PhD in computer science and has extensively worked on user experience design. His wife, a translator currently busy homeschooling their daughters, helps in the design of the educational apps. Watching their kids ? 6 and 9 years-old ? learn and play is their main source of inspiration for the apps they create. Copyright (C) 2012 L?Escapadou. All Rights Reserved. Apple, the Apple logo, iPhone, iPod and iPad are registered trademarks of Apple Inc. in the U.S. and/or other countries.

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Engineered flies spill secret of seizures

ScienceDaily (Oct. 11, 2012) ? Scientists have observed the neurological mechanism behind temperature-dependent -- febrile -- seizures by genetically engineering fruit flies to harbor a mutation analogous to one that causes epileptic seizures in people. In addition to contributing the insight on epilepsy, their new study also highlights the first use of genetic engineering to swap a human genetic disease mutation into a directly analogous gene in a fly.

In a newly reported set of experiments that show the value of a particularly precise but difficult genetic engineering technique, researchers at Brown University and the University of California-Irvine have created a Drosophila fruit fly model of epilepsy to discern the mechanism by which temperature-dependent seizures happen.

The researchers used a technique called homologous recombination -- a more precise and sophisticated technique than transgenic gene engineering -- to give flies a disease-causing mutation that is a direct analogue of the mutation that leads to febrile epileptic seizures in humans. They observed the temperature-dependent seizures in whole flies and also observed the process in their brains. What they discovered is that the mutation leads to a breakdown in the ability of certain cells that normally inhibit brain overactivity to properly regulate their electrochemical behavior.

In addition to providing insight into the neurology of febrile seizures, said Robert Reenan, professor of biology at Brown and a co-corresponding author of the paper in the Journal of Neuroscience, the study establishes

"This is the first time anyone has introduced a human disease-causing mutation overtly into the same gene that flies possess," Reenan said.

Engineering seizures

Homologous recombination (HR) starts with the transgenic technique of harnessing a transposable element (jumping gene) to insert a specially mutated gene just anywhere into the fly's DNA, but then goes beyond that to ultimately place the mutated gene into exactly the same position as the natural gene on the X chromosome. HR does this by outfitting the gene to be handled by the cell's own DNA repair mechanisms, essentially tricking the cell into putting the mutant copy into exactly the right place. Reenan's success with the technique allowed him to win a special grant from the National Institutes of Health last year.

The new paper is a result of that grant and Reenan's collaboration with neurobiologist Diane O'Dowd at UC-Irvine. Reenan and undergraduate Jeff Gilligan used HR to insert a mutated version of the para gene in fruit flies that is a direct parallel of the mutation in the human gene SCN1A that causes febrile seizures in people.

When the researchers placed flies in tubes and bathed the tubes in 104-degree F water, the mutant fruit flies had seizures after 20 seconds in which their legs would begin twitching followed by wing flapping, abdominal curling, and an inability to remain standing. After that, they remained motionless for as long as half an hour before recovering. Unaltered flies, meanwhile, exhibited no temperature-dependent seizures.

The researchers also found that seizure susceptibility was dose-dependent. Female flies with mutant strains of both copies of the para gene (females have two copies of the X chromosome) were the most susceptible to seizures. Those in whom only one copy of the gene was a mutant were less likely than those with two to seize, but more likely than the controls.

While the researchers at Brown compared the seizure susceptibility of whole flies, O'Dowd, lead author Lei Sun, and colleagues at Irvine studied individual fly neurons implicated in seizure activity to see how they behaved as the brains were heated. What their measurements revealed in the mutant flies were flaws in how "GABAergic" neurons take in sodium through channels in the cell membrane. Under normal circumstances, the neurons inhibit brain overactivity. But the mutants' mishandling of sodium led them to fail electrically.

"When [O'Dowd's team] isolates those currents due to the sodium channel, which is what's mutated in this case, and she compares the normal animals to the disease-model animals, what happens is the mutant channels pass too much current," Reenan said. "The channels open too easily and they take more effort to close. They open too soon and they close too late. That effect is magnified at higher temperature. Then the neuron can't send any [inhibitory] signals."

Searching for therapies

With a useful genetic model of epilepsy in fruit flies, Reenan said he is optimistic that researchers can now look for potential treatments for the disease. The next step, he said, is to use the practice of "forward genetics" to look for further mutations that might counter febrile seizures.

Given thousands of flies with model of the disease, scientists can purposely subject them to different DNA-altering conditions and then look to see if any flies lose their propensity for seizures. Among those that do, the researchers can then identify the specific genetic alteration responsible and determine whether that could ever be clinically applied. For example, if it turns out that a mutation proves therapeutic because it causes a certain protein to be overexpressed, then perhaps that protein could be refined into some kind of biologic pharmaceutical.

Reenan said he'd expect to see researchers follow a similar roadmap for other diseases as well.

"Knock-in of specific disease-causing mutations into the fly genome has the potential to provide a rapid and low-cost platform for studying the cellular mechanisms of heritable human diseases," the authors wrote. "In addition, knock-in flies can be used in combination with forward genetic screens to identify suppressor and/or enhancer mutations, a strategy that is challenging in humans and rodent models but well established in Drosophila."

In addition to Reenan, Gilligan, O'Dowd and Sun, other authors are Cynthia Staber of Brown and Ryan Schutte and Vivian Nguyen of UC Irvine.

In addition to the National Institutes of Health, the Howard Hughes Medical Institue and the Ellison Medical Foundation funded the research.

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The above story is reprinted from materials provided by Brown University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. L. Sun, J. Gilligan, C. Staber, R. J. Schutte, V. Nguyen, D. K. O'Dowd, R. Reenan. A Knock-In Model of Human Epilepsy in Drosophila Reveals a Novel Cellular Mechanism Associated with Heat-Induced Seizure. Journal of Neuroscience, 2012; 32 (41): 14145 DOI: 10.1523/JNEUROSCI.2932-12.2012

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/UMGo0WkKb3w/121011151623.htm

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